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Reglan is also used for a short time to treat heartburn cause by gastroesophageal reflux.

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Metoclopramide increases the tone and amplitude of gastricespecially antralcontractionsrelaxes the pyloric sphincter and the duodenal bulband increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transitIt increases the resting tone of the lower esophageal sphincterIt has littleif anyeffect on the motility of the colon or gallbladder.

If heartburn only occurs at certain timessuch as after the evening mealyour doctor may direct you to take a single dose before those times instead of taking it throughout the dayThis will reduce your risk of side effects.

The safety profile of metoclopramide in adults cannot be extrapolated to pediatric patientsDystonias and other extrapyramidal reactions associated with metoclopramide are more common in the pediatric population than in adultsSee WARNINGS and ADVERSE REACTIONSExtrapyramidal Reactions

The initial two doses should be 2 mg/kg if highly emetogenic drugs such as cisplatin or dacarbazine are used alone or in combinationFor less emetogenic regimens1 mg/kg per dose may be adequate.

There are insufficient reliable data to conclude whether the pharmacokinetics of metoclopramide in adults and the pediatric population are similarAlthough there are insufficient data to support the efficacy of metoclopramide in pediatric patients with symptomatic gastroesophageal refluxGERor cancer chemotherapy-related nausea and vomitingits pharmacokinetics have been studied in these patient populations.

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