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Losartan is a synthetic oral angiotensin-II receptortype AT 1antagonistAngiotensin IIa potent vasoconstrictoris the primary active hormone of the renin/angiotensin system and an important determinant of the pathophysiology of hypertensionAngiotensin II binds to the AT 1 receptor found in many tissuese.gvascular smooth muscleadrenal glandkidneys and the heartand elicits several important biological actionsincluding vasoconstriction and the release of aldosteroneAngiotensin II also stimulates smooth muscle cell proliferation.

Some antihypertensive drugs have smaller blood pressure effectsas monotherapyin black patientsand many antihypertensive drugs have additional approved indications and effectse.gon anginaheart failureor diabetic kidney diseaseThese considerations may guide selection of therapy.

Losartan is not recommended in children with glomerular filtration rate 2 as no data are availablesee section 4.2

Your blood pressure will need to be checked oftenYou may need other blood and urine tests at your doctor’s office.

Losartan is also not recommended in children with hepatic impairmentsee also section 4.4

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