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Estrogens increase the risk of gallbladder diseaseDiscontinue estrogen if hypercalcemiasudden partial or complete loss of visionhypertriglyceridemiaor cholestatic jaundice occursPatients dependent on thyroid hormone replacement therapy should have their thyroid function monitored in order to maintain their free thyroid hormone levels in an acceptable rangeEndometriosis may be exacerbated in women treated post-hysterectomy with estrogen-alone therapyThe addition of progestins should be considered in these patients.

There arehoweverpossible risks which may be associated with the use of progestins with estrogens compared to estrogen-alone regimensThese include a possible increased risk of breast cancer.

Suggested dosage is 1 to 2 mg three times dailyThe effectiveness of therapy can be judged by phosphatase determinations as well as by symptomatic improvement of the patient.

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according to ims health, market sales of estrace cream over the last 12 months were approximately 457 million.

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