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This study examined two groups of pa-the introduction of isotretinoin and a better manage- tients simultaneously irradiated twice a week with a high-ment of its usage successfully solve nearly all cases of intensity fiber optic lamp emitting visible light in the vio-acne.

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Although the exact mode of action of tretinoin is unknowncurrent evidence suggests that topical tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formationAdditionallytretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells causing extrusion of the comedones.

Long-term animal studies to determine the carcinogenic potential of tretinoin have not been performedStudies in hairless albino mice suggest that tretinoin may accelerate the tumorigenic potential of weakly carcinogenic light from a solar simulatorIn other studieswhen lightly pigmented hairless mice treated with tretinoin were exposed to carcinogenic doses of UVB lightthe incidence and rate of development of skin tumors was reducedDue to significantly different experimental conditionsno strict comparison of these disparate data is possibleAlthough the significance of these studies to man is not clearpatients should avoid or minimize exposure to sun.

Weather extremessuch as wind or coldalso may be irritating to patients under treatment with tretinoinRETIN-Atretinoinacne treatment should be kept away from the eyesthe mouthangles of the noseand mucous membranesTopical use may induce severe local erythema and peeling at the site of applicationIf the degree of local irritation warrantspatients should be directed to use the medication less frequentlydiscontinue use temporarilyor discontinue use altogetherTretinoin has been reported to cause severe irritation on eczematous skin and should be used with utmost caution in patients with this condition.

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sufferers with sunburn should be advised not to utilize tretinoin cream, usp emollient until totally recuperated.

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