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3Skinhair and nails Some indinavir users have reported thinner hair or temporary loss of hairDry skindry or cracked lipsand ingrown toenails have also been reported by indinavir usersThese symptoms are sometimes referred to as ectodermal dysplasiaFor more information about options to help manage this please see CATIE’s A Practical Guide to HIV Drug Side Effects

Table 9Established and Other Potentially Significant Drug InteractionsAlteration in Dose or Regimen May Be Recommended Based on Drug Interaction Studies or Predicted InteractionSee also CLINICAL PHARMACOLOGY for magnitude of interactionWARNINGS and DOSAGE AND ADMINISTRATION

Hyperbilirubinemia has occurred during treatment with CRIXIVANsee PRECAUTIONS and ADVERSE REACTIONSIt is unknown whether CRIXIVAN administered to the mother in the perinatal period will exacerbate physiologic hyperbilirubinemia in neonates.

In addition to adequate hydrationmedical management in patients who experience nephrolithiasis/urolithiasis may include temporary interruptione.g1 to 3 daysor discontinuation of therapy.

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conjugated estrogens; bazedoxifene moderate indinavir has been shown to decrease the metabolism of ethinyl estradiol; a similar interaction may occur with other estrogens used for hormone replacement therapy.

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