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Across all placebo-controlled trialsEVISTA was indistinguishable from placebo with regard to frequency and severity of breast pain and tendernessEVISTA was associated with less breast pain and tenderness than reported by women receiving estrogens with or without added progestin.

Raloxifene is an estrogen agonist/antagonistcommonly referred to as a selective estrogen receptor modulatorSERMThe biological actions of raloxifene are largely mediated through binding to estrogen receptorsThis binding results in activation of estrogenic pathways in some tissuesagonismand blockade of estrogenic pathways in othersantagonismThe agonistic or antagonistic action of raloxifene depends on the extent of recruitment of coactivators and corepressors to estrogen receptorERtarget gene promoters.

If EVISTA is given concomitantly with warfarin or other warfarin derivativesprothrombin time should be monitored more closely when starting or stopping therapy with EVISTAsee CLINICAL PHARMACOLOGY

Any unexplained uterine bleeding should be investigated as clinically indicatedEVISTA-treated and placebo-treated groups had similar incidences of endometrial proliferationsee Clinical Studies

Other side effectsdrug interactionsdosageand pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.

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evista may infrequently cause serious blood clots to form in the legs or lungs due to the lack of movement.

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