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Any chloride deficit during thiazide therapy is generally mild and usually does not require any specific treatment except under extraordinary circumstancesas in liver disease or renal diseaseDilutional hyponatremia may occur in edematous patients in hot weatherappropriate therapy is water restrictionrather than administration of saltexcept in rare instances when the hyponatremia is life threateningIn actual salt depletionappropriate replacement is the therapy of choice.

The thiazides may decrease arterial responsiveness to norepinephrineThis diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic useThiazides have also been shown to increase the responsiveness to tubocurarine.

OtherElevated liver enzymes have been reported in patients receiving MAXZIDE.

MAXZIDE is contraindicated in patients with anuriaacute and chronic renal insufficiency or significant renal impairment.

Tell your doctor and pharmacist if you are allergic to triamterene or any other medicationsDyazideMaxzidedo not take triamterene if you are taking amilorideMidamorspironolactoneAldactoneor other medications containing triamterenetell your doctor and pharmacist what prescription and nonprescription medicationsvitaminsnutritional supplementsand herbal products you are taking or plan to takeBe sure to mention angiotensin-converting enzymeACEinhibitors such as benazeprilLotensincaptoprilCapotenenalaprilVasotecfosinoprilMonoprillisinoprilPrinivilZestrilmoexiprilUnivascperindoprilAceonquinaprilAccuprilramiprilAltaceand trandolaprilMaviklithiumEskalithLithobidnonsteroidal anti-inflammatory medicationsNSAIDSsuch as ibuprofenAdvilMotrinand naproxenAleveNaprosynmedications for diabetesor high blood pressureother diureticsand potassium supplementsYour doctor may need to change the doses of your medications or monitor you carefully for side effectstell your doctor if you have or have ever had diabetesgoutkidney stonesor heartkidneyor liver diseasetell your doctor if you are pregnant or plan to become pregnantIf you become pregnant while taking triamterenecall your doctorDo not breastfeed if you are taking triamtereneif you are having surgeryincluding dental surgerytell the doctor or dentist that you are taking triamtereneplan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothingsunglassesand sunscreenTriamterene may make your skin sensitive to sunlight.

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