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Any chloride deficit during thiazide therapy is generally mild and usually does not require any specific treatment except under extraordinary circumstancesas in liver disease or renal diseaseDilutional hyponatremia may occur in edematous patients in avodart 0.5 mg buy. hot weatherappropriate therapy is water restrictionrather than administration of saltexcept in rare instances when the hyponatremia is life threateningIn actual salt depletionappropriate replacement is the therapy of choice.

The thiazides may decrease arterial responsiveness to norepinephrineThis diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic useThiazides have also been shown to increase the responsiveness to tubocurarine.

OtherElevated liver enzymes have been reported in patients receiving MAXZIDE.

MAXZIDE is contraindicated in patients with anuriaacute and chronic renal insufficiency or significant renal impairment.

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