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In accordance with this selective action, in vitro studies have indicated that, in contrast to tricyclic antidepressants, paroxetine has little affinity for alpha1, alpha2 and beta-adrenoceptors, dopamine d2 , 5-ht1 like, 5-ht2 and histamine h1 receptors.

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AGenerally acceptableControlled studies in pregnant women show no evidence of fetal risk.

High levels of serotonin in the bodyagitationhallucinationsfeverfast heart rateoveractive reflexesnauseavomitingdiarrhealoss of coordinationfainting;

XDo not use in pregnancyRisks involved outweigh potential benefitsSafer alternatives exist.

CUse with caution if benefits outweigh risksAnimal studies show risk and human studies not available or neither animal nor human studies done.

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patients receiving doses of 40 and 60 mg paroxetine experienced a mean reduction of approximately 6 and 7 points, respectively, on the ybocs total score which was significantly greater than the approximate 4-point reduction at 20 mg and a 3-point reduction in the placebo-treated patients.

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