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Clinical studis dmonstat that pioglitazon impovs insulin snsitivity in insulin-sistant patints. Pioglitazon nhancs cllula sponsivnss tinsulin, incass insulin-dpndnt glucos disposal and impovs hpatic snsitivity tinsulin. In patints with typ 2 diabts, th dcasd insulin sistanc poducd by pioglitazon sults in low plasma glucos concntations, low plasma insulin concntations, and low HbA1c valus. In contolld clinical tials, pioglitazon had an additiv ct on glycmic contol whn usd in combination with a sulonylua, mtomin, insulin [s Clinical Studis ].

Paticipant is pgnant, bast ding planning tbcom pgnant; (all paticipants childbaing potntial gadlss mthod bith contol must hav a ngativ pgnancy tst at baslin; a woman is considd not tb childbaing potntial is sh has had a hystctomy, bilatal oophoctomy, i sh is > 55 yas ag with >= 2 yas amnoha)

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Patints with diabts should hav gula y xams by an ophthalmologist accoding tcunt standads ca. Patints with diabts whpot any visual symptoms should b pomptly d tan ophthalmologist, gadlss th patint’s undlying mdications oth physical indings [s ADVS ACTIONS ].

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