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There are several readily identifiable causes of reduced theophylline clearanceIf the total daily dose is not appropriately reduced in the presence of these risk factorssevere and potentially fatal theophylline toxicity can occurCareful consideration must be given to the benefits and risks of theophylline use and the need for more intensive monitoring of serum theophylline concentrations in patients with the following risk factors:

Treatment of cardiac arrhythmias Sinus tachycardia and simple ventricular premature beats are not harbingers of life-threatening arrhythmiasthey do not require treatment in the absence of hemodynamic compromiseand they resolve with declining serum theophylline concentrationsOther arrhythmiasespecially those associated with hemodynamic compromiseshould be treated with antiarrhythmic therapy appropriate for the type of arrhythmia.

Do not crush or chew the capsules or tabletsDoing so can release all of the drug at onceincreasing the risk of side effectsAlsodo not split the tablets unless they have a score line and your doctor or pharmacist tells you to do soSwallow the whole or split tablet without crushing or chewing.

Miscellaneous Other factors associated with decreased theophylline clearance include the third trimester of pregnancysepsis with multiple organ failureand hypothyroidismCareful attention to dose reduction and frequent monitoring of serum theophylline concentrations are required in patients with any of these conditionssee WARNINGSOther factors associated with increased theophylline clearance include hyperthyroidism and cystic fibrosis.

This may not be a complete list of all interactions that may occurAsk your health care provider if Quibron-T may interact with other medicines that you takeCheck with your health care provider before you startstopor change the dose of any medicine.

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